Maternalalmondex, a neurogenic gene, is required for proper subcellular Notch distribution in earlyDrosophilaembryogenesis
نویسندگان
چکیده
منابع مشابه
The Notch-Regulated Ankyrin Repeat Protein Is Required for Proper Anterior–Posterior Somite Patterning in Mice
The Notch-regulated ankyrin repeat protein (Nrarp) is a component of a negative feedback system that attenuates Notch pathway-mediated signaling. In vertebrates, the timing and spacing of formation of the mesodermal somites are controlled by a molecular oscillator termed the segmentation clock. Somites are also patterned along the rostral-caudal axis of the embryo. Here, we demonstrate that Nra...
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Presenilins are a highly conserved family of proteins first identified as causative genes in early onset familial Alzheimer's disease. Recent studies have suggested a role for presenilins in the Notch-signaling pathway, but their specific function within this pathway remains unclear. Here, we have characterized the Drosophila presenilin gene and protein and studied their interaction with Notch ...
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Protein O-fucosyltransferase 1 (Pofut1), which catalyzes the addition of O-linked fucose to the EGF domains of the Notch receptor, is indispensable for Notch signaling activation. However, the mechanism of action of Pofut1 in mice is still unclear. Mouse embryos lacking Pofut1 shows defects in valve formation and trabeculation in the cardiovascular system, which are almost identical abnormaliti...
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متن کاملPAKc is required for proper chemotaxis
Running title: PAK control of chemotaxis 2 SUMMARY We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gβγ binding domain of ...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2019
ISSN: 0012-1592,1440-169X
DOI: 10.1111/dgd.12639